http://www.spinalrepair.org/research daily 0.75 2021-10-06 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1424269329670-FNTBMT4S2IULO0E3CRFD/lungs.jpg The Research - Breathing after spinal cord injury Maintenance of life among higher vertebrates depends on permanent, rhythmic and coordinated activity of respiratory muscles. The act of drawing air in and out of the lungs is one of the most basic, life-sustaining behaviors that we perform. More than half of the spinal cord injuries that occur in people affect their ability to breath (respiratory function). Motoneurons in the spinal cord that innervate respiratory muscles can be damaged and lost following spinal cord injury, which affects muscle function. In addition, axons from the brain and brainstem that send respiratory signals to these spinal motoneurons can be damaged which impairs motoneuron (and thus muscle) function. Respiratory muscles are innervated by neurons that are distributed throughout nearly the entire spinal cord (from the neck - or cervical levels - to lower spinal cord - or lumbar levels). This is illustrated in the figure below (taken from Lane (2011), Resp. Physiol. Neurobiol.) Therefore, an injury at nearly any level of the spinal cord can affect control of breathing in some way. The most devastating consequences occur following cervical level injuries. Injuries at this level compromise pathways from the brain to neurons at lower spinal cord levels. In addition, cervical level injuries can directly compromise the 'phrenic' motor system. Phrenic motor neurons innervate the diaphragm - often considered the main muscle of breathing. High or mid-cervical SCIs lead to impaired diaphragm function (paresis or paralysis). People with injuries at these levels often lose voluntary control of breathing and require 'assisted' ventilation (e.g. by mechanical ventilation, or diaphragm pacing). Assisted ventilation represents the most effective means of care for people unable to control breathing on their own, but several lines of research are now investigating whether there are ways to improve on these strategies, or alternative approaches to promoting recovery of breathing. Our research team is studying how breathing – and activity in respiratory muscles - is affected by cervical SCI, exploring the potential for spontaneous neuroplasticity, and trying to identify therapeutic strategies capable of promoting improvement in respiratory function. https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1423543571747-2DN4AQDGNG513IO4XBVJ/Cell+therapy.jpg The Research Although promoting long-distance regrowth of injured axons has been a longstanding objective of spinal cord injury (SCI) research, there is now wide-spread appreciation for the contribution of intrinsic neuroplastic axonal growth (i.e., short-distance intraspinal sprouting) to spontaneous functional recovery. Spinal interneurons are identified as an essential component of this plasticity and contribute to the formation of new anatomical pathways following SCI, that can re-route information around the site of injury. In effect, such “by-pass” pathways constitute neural relays that contribute to functional improvements. Our research team believes that treatments capable of harnessing and enhancing this natural plasticity may circumvent the need for long-range axonal growth. Accordingly, we believe that spinal interneurons are a key therapeutic target for optimizing anatomical repair and functional recovery following SCI. https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1424056291623-GQKQ5K8S5KJT4LO269P5/Injury+diagram+2.jpg The Research http://www.spinalrepair.org/news daily 0.75 2022-02-25 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1424036607043-BK8BYRKG3DGD6OTA6U5H/DSC_0110c.jpg News http://www.spinalrepair.org/news/2022/2/24/podcast-interview-with-jake-chalfin monthly 0.5 2022-02-25 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/35da039d-3783-4cb9-b71f-a882d547b6f4/IMG_8052.jpg News - Podcast interview with Jake Chalfin - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://www.spinalrepair.org/news/2022/2/24/congratulations-to-yashvi-shah monthly 0.5 2022-02-25 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/85616778-de4f-44ca-99a5-f5c347c5eb9d/Yashvi+S.JPG News - 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Another paper released http://www.spinalrepair.org/news/2018/1/6/hot-off-the-press monthly 0.5 2018-01-07 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1515296829591-EJYFYSIVWWPVKBHUCNGR/Untitled-1.jpg News - Hot off the press! http://www.spinalrepair.org/news/2017/12/29/podcast-interview monthly 0.5 2017-12-30 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1514596752332-F8HWFS00B24A1EM4UZJU/U2FPLongFinal-300x178.jpg News - Podcast Interview http://www.spinalrepair.org/news/2017/12/13/dr-victoria-spruance monthly 0.5 2017-12-14 https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1513225265341-4W978BZ9E3IBZGU2R1D1/File+Dec+13%2C+10+38+54+PM.jpeg News - Dr. Victoria Spruance https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1513225264078-JR6PFT7U9HFCCHRLIZ5D/File+Dec+13%2C+10+38+36+PM.jpeg News - Dr. Victoria Spruance https://images.squarespace-cdn.com/content/v1/54d96b31e4b0fd1bf8de348a/1513225268096-9EGH04P5XTQEW23RTS2C/File+Dec+13%2C+10+38+21+PM.jpeg News - 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